業績

原著論文(*Corresponding author)

  1. Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro-Oonuma T, Hwang Y, Ahn S, Park I, Ikeda W, Kusuhara S, Fukushima Y, Nara H, Sakai H, Fujiwara T, Matsushita J, Ema M, Hirashima M, Minami T, Shibuya M, Takakura N, Kim P, Miyata T, Ogura Y, *Uemura A.
    Sustained inflammation after pericyte depletion induces irreversible blood–retina barrier breakdown.
    JCI Insight. 2:e90905, 2017.
  2. Liu X, Uemura A, Fukushima Y, Yoshida Y, Hirashima M.
    Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1.
    Cell Rep. 17:2299-2311, 2016.
  3. Tomiyasu T, Hirano Y, Yoshida M, Suzuki N, Nishiyama T, Uemura A, Yasukawa T, Ogura Y.
    Microaneurysms cause refractory macular edema in branch retinal vein occlusion.
    Sci Rep. 6:29445, 2016.
  4. Suzuki N, Hirano Y, Tomiyasu T, Esaki Y, Uemura A, Yasukawa T, Yoshida M, Ogura Y.
    Retinal hemodynamics seen on optical coherence tomography angiography before and after treatment of retinal vein occlusion.
    Invest Ophthalmol Vis Sci. 57:5681-5687, 2016.
  5. Kachi I, Yasukawa T, Kato A, Takase N, Morita H, Kubota A, Hirano Y, Uemura A, Ogura Y.
    Combination therapy with intravitreal tissue plasminogen activator and ranibizumab for subfoveal type 2 choroidal neovascularization.
    Jpn J Ophthalmol. 60:179-186, 2016.
  6. D’Amato G, Luxan G, del Monte-Nieto G, Martinez-Poveda B, Torroja C, Walter W, Bochter MS, Benedito R, Cole S, Martinez F, Hadjantonakis AK, Uemura A, Jimenez-Borreguero LJ, de la Pompa JL.
    Sequential Notch activation regulates ventricular chamber development.
    Nat Cell Biol. 18:7-20, 2016.
  7. Suzuki N, Hirano Y, Yoshida M, Tomiyasu T, Uemura A, Yasukawa T, Ogura Y.
    Microvascular abnormalities imaged by optical coherence tomography angiography and fluorescein angiography in macular edema associated with branch retinal vein occlusion.
    Am J Ophthalmol. 161:126-132, 2016.
  8. Sugihara K, Nishiyama K, Fukuhara S, Uemura A, Arima S, Kobayashi R, Kohn-Luque A, Mochizuki N, Suda T, Ogawa H, Kurihara H.
    Autonomy and non-autonomy of angiogenic cell movements revealed by experiment-driven mathematical modeling.
    Cell Rep. 13:1814-1827, 2015.
  9. Yang WJ, Hu J, Uemura A, Tetzlaff F, Augustin HG, Fischer A.
    Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis.
    EMBO Mol Med. 7:1267-1284, 2015.
  10. Ogura S, Yasukawa T, Kato A, Kuwayama S, Hamada S, Hirano Y, Uemura A, Yoshida M, Ogura Y.
    Indocyanine Green Angiography-Guided Assessment and Laser Photocoagulation for Diffuse Diabetic Macular Edema.
    Ophthalmologica. 234:139-150, 2015.
  11. Kim C, Yang H, Fukushima Y, Saw PE, Lee J, Park JS, Park I, Jung J, Kataoka H, Lee D, Heo WD, Kim I, Jon S, Adams RH, Nishikawa S, *Uemura A, *Koh GY.
    Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption.
    Cancer Cell 25:102-117, 2014.
  12. Suda K, Guo C, Oishi A, Ikeda S, Uemura A, Yoshimura N.
    Therapeutic potential of semaphorin 3E for the treatment of choroidal neovascularization.
    Invest Ophthalmol Vis Sci. 55:4700-4706, 2014.
  13. Shimizu I, Yoshida Y, Moriya J, Nojima A, Uemura A, KobayashI Y, Minamino T.
    Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity.
    Cell Metab. 18:491-504, 2013.
  14. Katsuta H, Fukushima Y, Maruyama K, Hirashima M, Nishida K, Nishikawa S, *Uemura A.
    EphrinB2-EphB4 signals regulate formation and maintenance of funnel-shaped valves in corneal lymphatic capillaries.
    Invest Ophthalmol Vis Sci. 54:4102-4108, 2013.
  15. Felcht M, Luck R, Schering A, Seidel P, Srivastava K, Hu J, Bartol A, Kienast Y, Vettel C, Loos EK, Kutschera S, Bartels S, Appak S, Besemfelder E, Terhardt D, Chavakis E, Wieland T, Klein C, Thomas M, Uemura A, Goerdt S, Augustin HG.
    Angiopoietin-2 differentially regulates angiogenesis through Tie2 and integrin signaling.
    J Clin Invest. 122:1991-2005, 2012.
  16. Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M, Mochizuki N.
    The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice.
    J Clin Invest. 122:1416-1426, 2012.
  17. Toyofuku T, Nojima S, Ishikawa T, Takamatsu H, Tsujimura T, Uemura A, Matsuda J, Seki T, Kumanogoh A.
    Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival.
    Genes Dev. 26:816-829, 2012.
  18. Kurogane Y, Miyata M, Kubo Y, Nagamatsu Y, Kundu RK, Uemura A, Ishida T, Quertermous T, Hirata K, Rikitake Y.
    FGD5 mediates pro-angiogenic action of vascular endothelial growth factor in human vascular endothelial cells.
    Arterioscler Thromb Vasc Biol. 32:988-996, 2012.
  19. Kusuhara S, Fukushima Y, Fukuhara A, Jakt LM, Okada M, Shimizu Y, Hata M, Nishida K, Negi A, Hirashima M, Mochizuki N, Nishikawa S, *Uemura A.
    Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells.
    PLoS ONE. 7:e45858, 2012.
  20. Fukushima Y, Okada M, Kataoka H, Hirashima M, Yoshida Y, Mann F, Gomi F, Nishida K, Nishikawa S, *Uemura A.
    Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice.
    J Clin Invest. 121:1974-1985, 2011.
  21. Moriya J, Minamino T, Tateno K, Okada S, Uemura A, Shimizu I, Yokoyama M, Nojima A, Okada M, Koga H, Komuro I.
    Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis.
    Circ Res. 106:391-398, 2010.
  22. Elmi M, Matsumoto Y, Zeng ZJ, Lakshminarasimhan P, Yang W, Uemura A, Nishikawa S, Moshiri A, Tajima N, Agren H, Funa K.
    TLX activates MASH1 for induction of neuronal lineage commitment of adult hippocampal neuroprogenitors.
    Mol Cell Neurosci. 45:121-131, 2010.
  23. Tagami M, Kusuhara S, Imai H, Uemura A, Honda S, Tsukahara Y, Negi A.
    MRP4 knockdown enhances migration, suppresses apoptosis, and produces aggregated morphology in human retinal vascular endothelial cells.
    Biochem Biophys Res Commun. 400:593-598, 2010.
  24. Shimozono M, Uemura A, Hirami Y, Ishida K, Kurimoto Y.
    Corneal spherical aberration of eyes with cataract in a Japanese population.
    J Refract Surg. 26:457-459, 2010.
  25. Egawa G, Osawa M, Uemura A, Miyachi Y, Nishikawa S.
    Transient expression of ephrin B2 in perinatal skin is required for maintenance of keratinocyte homeostasis.
    J Invest Dermatol. 129:2386-2395, 2009.
  26. *Uemura A, Kusuhara S, Wiegand SJ, Yu RT, Nishikawa S.
    Tlx acts as a pro-angiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes.
    J Clin Invest. 116:369-377, 2006.
  27. Ozawa MG, Yao VJ, Chanthery YH, Troncoso P, Uemura A, Varner AS, Kasman IM, Pasqualini R, Arap W, McDonald DM.
    Angiogenesis with pericyte abnormalities in a transgenic model of prostate carcinoma.
    Cancer 104:2104-2115, 2005.
  28. Hisatsune H, Matsumura K, Ogawa M, Uemura A, Kondo N, Yamashita JK, Katsuta H, Nishikawa S, Chiba T, Nishikawa S.
    High level of endothelial cell-specific gene expression by a combination of the 5′ flanking region and the 5′ half of the first intron of the VE-cadherin gene.
    Blood 105:4657-4663, 2005.
  29. Miyawaki T, Uemura A, Dezawa M, Yu RT, Ide C, Nishikawa S, Honda Y, Tanabe Y, Tanabe T.
    Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina.
    J Neurosci. 24:8124-8134, 2004.
  30. Watanabe D, Takagi H, Suzuma K, Suzuma I, Oh H, Ohashi H, Kemmochi S, Uemura A, Ojima T, Suganami E, Miyamoto N, Sato Y, Honda Y.
    Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization.
    Am J Pathol. 164:1827-1835, 2004.
  31. Ohashi H, Takagi H, Oh H, Suzuma K, Suzuma I, Miyamoto N, Uemura A, Watanabe D, Murakami T, Sugaya T, Fukamizu A, Honda Y.
    Phosphatidylinositol 3-kinase/Akt regulates angiotensin II-induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and suppression of caspase-3 activity.
    Circ Res. 94:785-793, 2004.
  32. *Uemura A, Ogawa M, Hirashima M, Fujiwara T, Koyama S, Takagi H, Honda Y, Wiegand SJ, Yancopoulos GD, Nishikawa S.
    Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells.
    J Clin Invest. 110:1619-1628, 2002.
  33. Oh H, Takagi H, Otani A, Koyama S, Kemmochi S, Uemura A, Honda Y.
    Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis.
    Proc Natl Acad Sci USA. 99:383-388, 2002.

欧文総説・著書(*Corresponding author)

  1. *Uemura A.
    Identification of novel drug targets for the treatment of diabetic retinopathy.
    Diabetes Metab J. 37:217-224, 2013.
  2. *Uemura A.
    Stability and functional integrity of new blood vessels.
    Encyclopedia of the Eye, Vol4. Oxford: Academic Press. 204-211, 2010.
  3. *Uemura A.
    Pharmacological treatment of retinopathy of prematurity: anti-angiogenic or pro-angiogenic?
    Expert Rev Ophthalmol. 5:123-127, 2010.
  4. *Uemura A, Kusuhara S, Katsuta H, Nishikawa S.
    Angiogenesis in the mouse retina: a model system for experimental manipulation.
    Exp Cell Res. 312:676-683, 2006.

和文総説・著書

  1. 植村明嘉. 糖尿病網膜症 病態メカニズムと創薬開発. プラクティス 33:541-544, 2016.
  2. 植村明嘉. 糖尿病網膜症に対する創薬開発. 糖尿病合併症 30:64-66, 2016.
  3. 植村明嘉. 糖尿病網膜症に対する創薬開発. 医学のあゆみ 255:138-141, 2015.
  4. 植村明嘉. 網膜血管新生における網羅遺伝子発現解析. 血管医学 14:369-375, 2013.
  5. 植村明嘉. 網膜症における血管新生. 糖尿病合併症 27:72-75, 2013.
  6. 植村明嘉. 糖尿病網膜症に対する新規創薬標的分子の探索. 日本糖尿病眼学会誌 18:26-28, 2013.
  7. 植村明嘉. Semaphorin-Plexin. 血管新生研究の最先端 医薬ジャーナル社 112-118, 2013.
  8. 植村明嘉. Sema3E-PlexinD1シグナルを標的とした網膜血管再生療法の開発. Retina Medicine. 1:78-79, 2012.
  9. 植村明嘉. 網膜血管の発生. 血管生物医学事典 朝倉書店 183-184, 2011.
  10. 植村明嘉. Semaphorin. 血管生物医学事典 朝倉書店 263-265, 2011.
  11. 植村明嘉. 網膜血管新生におけるガイダンス分子の役割. 日本臨床 68:349-353, 2010.
  12. 植村明嘉. 網膜における生理的血管発生と病的血管新生. 実験医学 28:2825-2830, 2010.
  13. 植村明嘉. 中心窩にはなぜ血管がないのか? 眼のサイエンス 視覚の不思議 146-147, 2010.
  14. 植村明嘉. 網膜血管網の形成におけるガイダンス分子の役割. 実験医学 27:1710-1714, 2009.
  15. 植村明嘉. 糖尿病網膜症における機能的血管再生へのあたらしいアプローチ. 日本臨床 66:167-170, 2008.
  16. 植村明嘉. 糖尿病網膜症における機能的血管再生に向けた発生期網膜血管新生の研究. 糖尿病合併症 22:128-131, 2008.
  17. 植村明嘉. 新生血管を網膜内に誘導するには? あたらしい眼科 25:1115-1117, 2008.
  18. 植村明嘉、西川伸一. 血管リモデリングを制御する細胞・分子メカニズム. 医学のあゆみ 221:1135-1138, 2007.
  19. 植村明嘉. 網膜血管の伸長方向を制御する分子メカニズム. 医学のあゆみ 223:1029-1033, 2007.
  20. 植村明嘉. 網膜血管の足場を作るスイッチ蛋白質Tlx. 検査と技術 35:177-178, 2007.
  21. 植村明嘉. 網膜血管発生の細胞・分子メカニズム. 細胞 38:363-366, 2006.
  22. 植村明嘉、西川伸一. 網膜血管発生の細胞生物学. 実験医学 24:2761-2766, 2006.
  23. 植村明嘉、高木均. 細胞増殖因子と糖尿病網膜症. 現代医療 35:2153-2160, 2003.
  24. 植村明嘉、小川峰太郎、西川伸一. 血管系の発生と形態形成. 実験医学 20:1084-1090, 2002.